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Product > Antibody > P16 Monoclonal Antibody
P16 Monoclonal Antibody
P16 Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 2D9A12
Host: Mouse
Reactivity:Human, Rat
Applications: IHC
Product Summary
Size:
50μL
Clonality: 2D9A12
Host: Mouse
Reactivity: Human,Rat
Applications: IHC
Product overview
Code
BT-MCA4176
Host
Mouse
Isotype
Mouse IgG2b
Size
50μL
Clonality
2D9A12
Immunogen
Purified recombinant fragment of P16 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
The progression of cells through the cell cycle is regulated by a family of protein kinases known as cyclin-dependent kinases (Cdks). The sequential activation of individual members of this family and their consequent phosphorylation of critical substrates promotes orderly progression through the cell cycle. The cyclins function as differentially expressed positive regulators of Cdks. Negative regulators of the cycle include the p53-inducible 21 kDa WAF1/Cip1 protein designated p21, Kip1 p27 and p16. The complexes formed by Cdk4 and the D-type cyclins have been strongly implicated in the control of cell proliferation during the G1 phase. It has recently been shown that p16 binds to Cdk4 and inhibits the catalytic activity of the Cdk4/cyclin D complex. Moreover, the gene encoding p16 exhibits a high frequency of homozygous deletions and point mutations in established human tumor cell lines.
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