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Product > Antibody > GSK3 alpha Monoclonal Antibody
GSK3 alpha Monoclonal Antibody
GSK3 alpha Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 6G12C2
Host: Mouse
Reactivity:Human
Applications: WB
Product Summary
Size:
50μL
Clonality: 6G12C2
Host: Mouse
Reactivity: Human
Applications: WB
Product overview
Code
BT-MCA3051
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
6G12C2
Immunogen
Purified recombinant fragment of GSK3 alpha expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
Glycogen synthase kinase 3 alpha belongs to the Ser/Thr family of protein kinases, Cdc2/cdkx subfamily,GSK3 subsubfamily. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, myb, and the transcription factor c jun. GSK3 phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK3 and subsequently inhibits GSK3 acutely leading to the stimulation of glycogen synthesis. GSK3 signaling is performed by two isoforms, GSK3 alpha and GSK3 beta. The two isoforms share 97% sequence similarity within their catalytic domains. GSK3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics and cell motility.
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