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Product > Antibody > Human P16 Monoclonal Antibody
Human P16 Monoclonal Antibody
Human P16 Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 5A8A4; 3G8D12
Host: Mouse
Reactivity:Human
Applications: IHC
Product Summary
Size:
50μL
Clonality: 5A8A4; 3G8D12
Host: Mouse
Reactivity: Human
Applications: IHC
Product overview
Code
BT-MCA3472
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
5A8A4; 3G8D12
Immunogen
Purified recombinant fragment of P16 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
p16 (cyclin-dependent kinase inhibitor 2A, INK4a) is a tumor suppressor protein. It is a specific inhibitor of Cdk 4 / Cdk 6, and a tumor suppressor involved in the pathogenesis of a variety of malignancies. Recent analyses of the p16 INK4a gene revealed homozygous deletions, nonsense, missense, or frameshift mutations in several human cancers. Although the frequency of p16 INK4a abnormalities is higher in tumor derived cell lines than in unselected primary tumors, significant subsets of clinical cases with aberrant p16 INK4a gene have been reported among melanomas, gliomas, esophageal, pancreatic, lung, and urinary bladder carcinomas, and some types of leukemia.
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