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Product > Antibody > Trim5a Monoclonal Antibody
Trim5a Monoclonal Antibody
Trim5a Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 3B11H2
Host: Mouse
Reactivity:Human
Applications: WB,IHC
Product Summary
Size:
50μL
Clonality: 3B11H2
Host: Mouse
Reactivity: Human
Applications: WB,IHC
Product overview
Code
BT-MCA4213
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
3B11H2
Immunogen
Purified recombinant fragment of human trim5 alpha expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
TRIM5-alpha is a protein that is found in the cells of many mammals and fends of various retrovirus infections. It protects monkeys from infection with HIV-1, and humans from infection with some other viruses. If a retrovirus has entered a cell, it needs to shed its capsid in order to reversely transcribe its genes, so that they can be expressed by the host cell. It is believed that TRIM5 alpha, which is present in the cytoplasm, somehow recognizes the capsid and blocks its shedding, thereby stopping the virus in its tracks. It thus represents an intracellular defense completely separate from the rest of the body's immune system.
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