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Product > Antibody > RB Monoclonal Antibody
RB Monoclonal Antibody
RB Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 7E4B8
Host: Mouse
Reactivity:Human
Applications: IHC
Product Summary
Size:
50μL
Clonality: 7E4B8
Host: Mouse
Reactivity: Human
Applications: IHC
Product overview
Code
BT-MCA2508
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
7E4B8
Immunogen
Purified recombinant fragment of human RB expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
The Rb protein regulates differentiation, apoptosis, and cell cycle control by coordinating the cell cycle at G1-S with transcriptional machinery. During G1, cyclin D-dependent kinase-mediated phosphorylation of Rb at Ser-795 marks the conversion of Rb from a transcriptionally repressive, hypophosphorylated state to an inactive, phosphorylated state, which may be sustained through mitosis by differential phosphorylation of up to 16 putative serine or threonine residues. Pediatric cancer retinoblastoma and the formation of other human tumors can be attributed to mutations in the retinoblastoma tumor suppressor gene(Rb).
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