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Product > Antibody > ZAP70 Monoclonal Antibody
ZAP70 Monoclonal Antibody
ZAP70 Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 3D2A4
Host: Mouse
Reactivity:Human
Applications: WB,IHC
Product Summary
Size:
50μL
Clonality: 3D2A4
Host: Mouse
Reactivity: Human
Applications: WB,IHC
Product overview
Code
BT-MCA2633
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
3D2A4
Immunogen
Purified recombinant fragment of human ZAP70 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
ZAP70 (zeta-chain associated protein kinase), a 70 kDa member of the SYK tyrosine kinase family, plays a central role in lymphocyte activation and development, and is implicated in several immune disorders. ZAP70 controls TCR(T-cell antigen receptor)-linked signal transduction pathways. Its key role in thymocytes development and mature T lymphocytes activation has been illustrated by the characterization of several human immunodeficiencies presenting with mutations in the ZAP70 gene. ZAP70 is also expressed in several types of B-cell neoplasm and is easily detected by immunohistochemistry, providing a useful prognostic marker in patients with chronic lymphocytic leukaemia.
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