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Product > Antibody > SNCA Monoclonal Antibody
SNCA Monoclonal Antibody
SNCA Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 2B2D1
Host: Mouse
Reactivity:Human
Applications: IHC
Product Summary
Size:
50μL
Clonality: 2B2D1
Host: Mouse
Reactivity: Human
Applications: IHC
Product overview
Code
BT-MCA3423
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
2B2D1
Immunogen
Purified recombinant fragment of SNCA expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
Alpha-synuclein (SNCA), with 140-amino acid protein (about 15kDa), belongs to the synuclein family, which also includes beta- and gamma-synuclein. SNCA is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). SNCA is implicated in the regulation of dopamine release and transport. The triplication of the SNCA can cause Parkinson disease (PD) and diffuse Lewy body disease within the same kindred. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Immunohistochemistry for SNCA has become the histological technique of choice for the diagnosis for Parkinson's disease, Dementia with Lewy bodies and Multiple System Atrophy.
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