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Product > Antibody > MSH6 Monoclonal Antibody
MSH6 Monoclonal Antibody
MSH6 Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 8E3A7
Host: Mouse
Reactivity:Human, Mouse
Applications: WB,IHC,FCM
Product Summary
Size:
50μL
Clonality: 8E3A7
Host: Mouse
Reactivity: Human,Mouse
Applications: WB,IHC,FCM
Product overview
Code
BT-MCA4844
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
8E3A7
Immunogen
Purified recombinant fragment of human MSH6 (AA: 217-395) expressed in E. Coli.
Formulation
Purified antibody in PBS with 0.05% sodium azide
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants.
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