BT-MCA2796

Mouse

Mouse IgG1

100μL,50μL

Monoclonal

Purified recombinant fragment of human ATP6V0A4 (AA: 228-390) expressed in E. Coli.

Purified antibody in PBS with 0.05% sodium azide

Store at 4°C short term. Aliquot and store at -20°C long term.

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. This gene is one of four genes in man and mouse that encode different isoforms of the a subunit. Alternatively spliced transcript variants encoding the same protein have been described. Mutations in this gene are associated with renal tubular acidosis associated with preserved hearing.

Q9HBG4:;

96.3kDa

50617

A4;STV1;VPH1;VPP2;DRTA3;RTA1C;RTADR;ATP6N2;RDRTA2;ATP6N1B

Others

ATP6V0A4