BT-MCA2093

Mouse

Mouse IgG2a

100μL,50μL

Monoclonal

Purified recombinant fragment of human DCLK2 (AA: 652-766) expressed in mammalian.

Purified antibody in PBS with 0.05% sodium azide

Store at 4°C short term. Aliquot and store at -20°C long term.

This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified.

Q8N568:;

83.6kDa

166614

CL2;DCK2;CLIK2;DCDC3;CLICK2;DCDC3B;DCAMKL2;CLICK-II

Signal Transduction

DCLK2