BT-MCA4266

Mouse

Mouse IgG1

100μL,50μL

Monoclonal

Purified recombinant fragment of human PTPRU (AA: extra 579-749) expressed in E. Coli.

Purified antibody in PBS with 0.05% sodium azide

Store at 4°C short term. Aliquot and store at -20°C long term.

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Alternatively spliced transcript variants have been reported.

Q92729:;

162.4kDa

10076

FMI;PTP;PCP-2;PTP-J;PTPRO;PTPU2;PTP-PI;PTP-RO;PTPPSI;hPTP-J;R-PTP-U;R-PTP-PSI

Signal transduction

PTPRU