CD46 Monoclonal Antibody

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Home > Product > Antibody > CD46 Monoclonal Antibody

CD46 Monoclonal Antibody

Product Summary

Size: 100μL,50μL

Clonality: Monoclonal

Host: Mouse

Reactivity:Human

Applications: WB,ICC,FCM

Product Summary

Size: 100μL,50μL

Clonality: Monoclonal

Host: Mouse

Reactivity: Human

Applications: WB,ICC,FCM

Product overview

Code

BT-MCA3419

Host

Mouse

Isotype

Mouse IgG1

Size

100μL,50μL

Clonality

Monoclonal

Immunogen

Purified recombinant fragment of human CD46 (AA: extra 35-179) expressed in E. Coli.

Formulation

Purified antibody in PBS with 0.05% sodium azide

Storage

Store at 4°C short term. Aliquot and store at -20°C long term.

Background

The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.

Uniprot accession

P15529:;

Molecular weight

43.7kDa

Gene ID

4179

Synonyms

MCP;TLX;AHUS2;MIC10;TRA2.10

Research area

Immunology

Target protein

CD46

Recommended dilution

Application	Dilution
WB	1:500 - 1:2000
ICC	1:100 - 1:500
FCM	1:200 - 1:400
ELISA	1:10000

Images

Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)

Western blot analysis using CD46 mAb against human CD46 (AA: extra 35-179) recombinant protein. (Expected MW is 42.4 kDa)

Western blot analysis using CD46 mAb against HEK293 (1) and CD46 (AA: extra 35-179)-hIgGFc transfected HEK293 (2) cell lysate.

Western blot analysis using CD46 mouse mAb against SW480 (1) and MCF-7 (2) cell lysate.

Immunofluorescence analysis of Hela cells using CD46 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)

Flow cytometric analysis of HL-60 cells using CD46 mouse mAb (green) and negative control (red).

Protocols

> Protocol Booklet

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Datasheet

Product size

Price

100μL

$320.00
50μL

$220.00

Add to Cart

Lead time: Within one week

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