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Home >
Product > Antibody > CD45 Monoclonal Antibody
CD45 Monoclonal Antibody
CD45 Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 1B9B10
Host: Mouse
Reactivity:Human
Applications: IHC,FCM
Product Summary
Size:
50μL
Clonality: 1B9B10
Host: Mouse
Reactivity: Human
Applications: IHC,FCM
Product overview
Code
BT-MCA3642
Host
Mouse
Isotype
Mouse IgG2b
Size
50μL
Clonality
1B9B10
Immunogen
Purified recombinant fragment of human CD45 (AA: extra 431-577) expressed in E. Coli.
Formulation
Purified antibody in PBS with 0.05% sodium azide
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.
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