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Product > Antibody > CD42B Monoclonal Antibody
CD42B Monoclonal Antibody
CD42B Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 6H6H10
Host: Mouse
Reactivity:Human
Applications: WB,IHC,FCM
Product Summary
Size:
50μL
Clonality: 6H6H10
Host: Mouse
Reactivity: Human
Applications: WB,IHC,FCM
Product overview
Code
BT-MCA4380
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
6H6H10
Immunogen
Purified recombinant fragment of human CD42B (AA: extra 17-183) expressed in E. Coli.
Formulation
Purified antibody in PBS with 0.05% sodium azide
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy.
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