BT-MCA3219

Mouse

Mouse IgG1

100μL,50μL

Monoclonal

Synthesized peptide of human Stat5 (AA: KAVDG[pTyr]VKPQIK).

Purified antibody in PBS with 0.05% sodium azide.

Store at 4°C short term. Aliquot and store at -20°C long term.

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene.

P42229:;

90.6kDa

6776

MGF;STAT5A

Others

Stat5