BT-MCA2866

Mouse

Mouse IgG1

100μL,50μL

Monoclonal

Purified recombinant fragment of human PRKCG (AA: 87-338) expressed in E. Coli.

Purified antibody in PBS with 0.05% sodium azide.

Store at 4°C short term. Aliquot and store at -20°C long term.

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).

P05129:;

78.4kDa

5582

PKCC;PKCG;SCA14;PKC-gamma

Signal Transduction

PRKCG