11 Beta-HSD1 Polyclonal Antibody

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Home > Product > Antibody > 11 Beta-HSD1 Polyclonal Antibody

11 Beta-HSD1 Polyclonal Antibody

Product Summary

Size: 20ul,50ul,100ul

Clonality: Polyclonal

Host: Rabbit

Reactivity:Human, Mouse, Rat

Applications: WB, IHC-p, ELISA

Product Summary

Size: 20ul,50ul,100ul

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC-p, ELISA

Product overview

Full product name

11beta-HSD1 Antibody

Code

BT-AP00001

Host

Rabbit

Isotype

IgG

Size

20ul,50ul,100ul

Clonality

Polyclonal

Immunogen

The antiserum was produced against synthesized peptide derived from human HSD11B1. AA range:1-50

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage

-20°C for one year

Background

Hydroxysteroid 11-beta dehydrogenase 1 encoded by HSD11B1 is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in HSD11B1 has been associated with obesity and insulin resistance in children. Mutations in HSD11B1 and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.

Uniprot accession

Human:;Mouse:;Rat:;

Molecular weight

32401

Gene ID

Human: 3290; Mouse: 15483; Rat: 25116

Synonyms

HSD11B1; HSD11; HSD11L; Corticosteroid 11-beta-dehydrogenase isozyme 1; 11-beta-hydroxysteroid dehydrogenase 1; 11-DH; 11-beta-HSD1

Research area

Signal Transduction; Cancer

Target protein

HSD11B1

Recommended dilution

Application	Dilution
WB	1: 500 - 1: 2000
IHC	1: 100 - 1: 300
ELISA	1: 40000

Images

Western blot analysis of the lysates from HUVECcells using HSD11B1 antibody.

Western Blot analysis of Hela cells using 11β-HSD1 Polyclonal Antibody

Immunohistochemistryt analysis of paraffin-embedded human breast carcinoma, using HSD11B1 Antibody. The lane on the right is blocked with the HSD11B1 peptide.

Western Blot analysis of various cells using 11β-HSD1 Polyclonal Antibody

Western blot analysis of HSD11B1 Antibody. The lane on the right is blocked with the HSD11B1 peptide.

Protocols

> Protocol Booklet

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Datasheet

Product size

Price

20ul

$108.00
50ul

$180.00
100ul

$275.00

Add to Cart

Lead time: Within one week

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