Product overview
Full product name
Code
Host
Isotype
Size
Clonality
Immunogen
Purification
Concentration
Formulation
Storage
Background
Cyclin D1 encoded by CCND1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. Cyclin D1 has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of CCND1, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
Uniprot accession
Molecular weight
Gene ID
Synonyms
Research area
Target protein
Recommended dilution
| Application | Dilution |
|---|---|
| WB | 1: 500 - 1: 2000 |
| IHC | 1: 50 - 1: 200 |
Images
Protocols
Customer reviews and Q&As
