GCK Polyclonal Antibody

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Home > Product > Antibody > GCK Polyclonal Antibody

GCK Polyclonal Antibody

Product Summary

Size: 20ul,50ul,100ul

Clonality: Polyclonal

Host: Rabbit

Reactivity:Human, Mouse, Rat

Applications: WB, ELISA

Product Summary

Size: 20ul,50ul,100ul

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, ELISA

Product overview

Full product name

GCK Antibody

Code

BT-AP03505

Host

Rabbit

Isotype

IgG

Size

20ul,50ul,100ul

Clonality

Polyclonal

Immunogen

The antiserum was produced against synthesized peptide derived from human GCK. AA range:43-92

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage

-20°C for one year

Background

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of GCK results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. Glucokinase localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).

Uniprot accession

Human:;Mouse:;Rat:;

Molecular weight

52191

Gene ID

Human: 2645; Mouse: 103988; Rat: 24385

Synonyms

GCK; Glucokinase; Hexokinase type IV; HK IV; Hexokinase-4; HK4; Hexokinase-D

Research area

Signal Transduction; Metabolism

Target protein

GCK

Recommended dilution

Application	Dilution
WB	1: 500 - 1: 2000
ELISA	1: 10000

Images

Western blot analysis of lysate from NIH/3T3 cells, using GCK antibody.

Western Blot analysis of various cells using GCK Polyclonal Antibody diluted at 1:1000

Western Blot analysis of NIH-3T3 cells using GCK Polyclonal Antibody diluted at 1:1000

Protocols

> Protocol Booklet

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Datasheet

Product size

Price

20ul

$108.00
50ul

$180.00
100ul

$275.00

Add to Cart

Lead time: Within one week

Custom quote | Bulk request

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