Glucocorticoid receptor Antibody

BT-AP03591

Rabbit

IgG

20ul,50ul,100ul

Polyclonal

Recombinant Protein of Glucocorticoid receptor

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.

1 mg/ml

PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.

-20°C for one year

NR3C1 encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. Nuclear receptor subfamily 3 group C member 1 is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in NR3C are associated with generalized glucocorticoid resistance. Alternative splicing of NR3C results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175).

Human:;Mouse:;Rat:;

85659

Human: 2908; Rat: 24413

NR3C1; GRL; Glucocorticoid receptor; GR; Nuclear receptor subfamily 3 group C member 1

Signal Transduction

NR3C1