GRB10 Polyclonal Antibody

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Home > Product > Antibody > GRB10 Polyclonal Antibody

GRB10 Polyclonal Antibody

Product Summary

Size: 20ul,50ul,100ul

Clonality: Polyclonal

Host: Rabbit

Reactivity:Human

Applications: WB, IHC-p, IF, ELISA

Product Summary

Size: 20ul,50ul,100ul

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Applications: WB, IHC-p, IF, ELISA

Product overview

Full product name

GRB10 Antibody

Code

BT-AP03803

Host

Rabbit

Isotype

IgG

Size

20ul,50ul,100ul

Clonality

Polyclonal

Immunogen

The antiserum was produced against synthesized peptide derived from human GRB10. AA range:33-82

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage

-20°C for one year

Background

Growth factor receptor-bound protein 10 belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. GRB10 encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. GRB10 is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified.

Uniprot accession

Human:;Mouse:;

Molecular weight

67231

Gene ID

Human: 2887

Synonyms

GRB10; GRBIR; KIAA0207; Growth factor receptor-bound protein 10; GRB10 adapter protein; Insulin receptor-binding protein Grb-IR

Research area

Signal Transduction

Target protein

GRB10

Recommended dilution

Application	Dilution
WB	1: 500 - 1: 2000
IHC	1: 100 - 1: 300
IF	1: 200 - 1: 1000
ELISA	1: 5000

Images

Western Blot analysis of various cells using GRB10 Polyclonal Antibody diluted at 1:2000

Western blot analysis of lysates from NIH/3T3 cells, treated with Insulin 0.01U/ml 15', using GRB10 Antibody. The lane on the right is blocked with the synthesized peptide.

Western Blot analysis of 3T3 cells using GRB10 Polyclonal Antibody diluted at 1:2000

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using GRB10 Antibody. The picture on the right is blocked with the synthesized peptide.

Immunofluorescence analysis of HepG2 cells, using GRB10 Antibody. The picture on the right is blocked with the synthesized peptide.

Protocols

> Protocol Booklet

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Datasheet

Product size

Price

20ul

$108.00
50ul

$180.00
100ul

$275.00

Add to Cart

Lead time: Within one week

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