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Home > Product > Antibody > MC1-R Polyclonal Antibody

MC1-R Polyclonal Antibody

MC1-R Polyclonal Antibody

Product Summary

Size: 20ul,50ul,100ul

Clonality: Polyclonal

Host: Rabbit

Reactivity:Human

Applications: WB, IF, ELISA

Product Summary

Size: 20ul,50ul,100ul

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Applications: WB, IF, ELISA

Product overview

Full product name

MC1-R Antibody

Code

BT-AP05261

Host

Rabbit

Isotype

IgG

Size

20ul,50ul,100ul

Clonality

Polyclonal

Immunogen

The antiserum was produced against synthesized peptide derived from human MSHR. AA range:268-317

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage

-20°C for one year

Background

This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that MC1R(MSH) is an important component in determining normal human pigment variation.

Uniprot accession

Molecular weight

34706

Gene ID

Human: 4157

Synonyms

MC1R; MSHR; Melanocyte-stimulating hormone receptor; MSH-R; Melanocortin receptor 1; MC1-R

Research area

Neuroscience

Target protein

MC1R

Recommended dilution

Application Dilution
WB 1: 500 - 1: 2000
IF 1: 200 - 1: 1000
ELISA 1: 5000

Images

Western blot analysis of lysates from COLO205 cells, using MSHR Antibody. The lane on the right is blocked with the synthesized peptide.
Immunofluorescence analysis of LOVO cells, using MSHR Antibody. The picture on the right is blocked with the synthesized peptide.
Western Blot analysis of COLO205 cells using MC1-R Polyclonal Antibody
Western blot analysis of the lysates from HepG2 cells using MSHR antibody.

Protocols

Customer reviews and Q&As

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Product size

Price

  • 20ul

    $108.00

  • 50ul

    $180.00

  • 100ul

    $275.00

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Lead time: Within one week

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