Product overview
Full product name
Code
Host
Isotype
Size
Clonality
Immunogen
Purification
Concentration
Formulation
Storage
Background
SELPLG encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, selectin P ligand plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.
Uniprot accession
Molecular weight
Gene ID
Synonyms
Research area
Target protein
Recommended dilution
Application | Dilution |
---|---|
WB | 1: 500 - 1: 2000 |
IHC-p | 1: 100 - 1: 300 |
ELISA | 1: 10000 |
Images
Protocols
Customer reviews and Q&As