Septin 5 Antibody

BT-AP08221

Rabbit

IgG

20ul,50ul,100ul

Polyclonal

Synthesized peptide derived from Septin 5 . at AA range: 180-260

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for one year

SEPT5 (septin 5) is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. SEPT5 is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and SEPT5 has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced.

Human:;Mouse:;Rat:;

42777

Human: 5413; Mouse: 18951; Rat: 116728

SEPT5; PNUTL1; Septin-5; Cell division control-related protein 1; CDCrel-1; Peanut-like protein 1

Cell Biology

SEPT5