Product overview
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Background
SIRT2 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of SIRT2.
Uniprot accession
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Target protein
Recommended dilution
Application | Dilution |
---|---|
WB | 1: 500 - 1: 2000 |
ELISA | 1: 2000 - 1: 20000 |
IHC | 1: 50 - 1: 300 |
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