Product overview
Full product name
Code
Host
Isotype
Size
Clonality
Immunogen
Purification
Concentration
Formulation
Storage
Background
Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of VHL is the basis of familial inheritance of VHL syndrome. The protein encoded by VHL is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Uniprot accession
Molecular weight
Gene ID
Synonyms
Research area
Target protein
Recommended dilution
| Application | Dilution |
|---|---|
| IHC | 1: 100 - 1: 300 |
| ELISA | 1: 40000 |
Images
Protocols
Customer reviews and Q&As
