Receptor tyrosine-protein kinase erbB-3

BPE044

Sandwich

5*96T,96T,15*96T

4.36 pg/mL

18.75-1200 pg/mL

Serum, plasma, cell culture supernates

Human

2-8°C

3.5h

ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form. Cancer Immunotherapy Immune Checkpoint Immunotherapy Targeted Therapy

148098

2065

HER3

ERBB3

Cancer,Signal transduction,Neuroscience

HER3