Product overview
Product name
Background
Malate Dehydrogenase (MDH) (EC 1.1.1.37) is an important enzyme which reversibly converts L-malate into oxaloacetate in the presence of NAD. In eukaryotic cells, malate dehydrogenase has 2 isoforms: MDH1 and MDH2. MDH1 is cytosolic & participates in the malateaspartate shuttle, which transports malate into mitochondria for utilization in ATP generation whereas MDH2 is a mitochondrial enzyme and part of the citric acid cycle. MDH activity is increased in some neurodegenerative diseases such as Alzheimer’s disease, and abnormal MDH activity in serum can serve as a diagnostic tool for severe liver damage (e.g. Hepatocellular carcinoma).
Storage
Target protein
Components
Components | Quantity |
---|---|
Liquid | 12ml × 5 vials |
Lyophilized powder | 2 vials |
Dilute | 0.5ml × 2 vials |
Lyophilized powder | 5 vials |
Diluent | 1ml × 5 vials |
Protocols
References
Customer reviews and Q&As