Annexin A1

E3288Hu

Sandwich

48T,96T

0.18ng/ml

0.3-90ng/ml

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed: 8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Promotes resolution of inflammation and wound healing (PubMed: 25664854). Functions at least in part by activating the formyl Peptide receptors and downstream signaling cascades (PubMed: 15187149, PubMed: 25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl Peptide receptors (PubMed: 15187149). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed: 17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed: 17008549). Has no effect on unstimulated T cells (PubMed: 17008549). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed: 15187149). Negatively regulates hormone exocytosis via activation of the formyl Peptide receptors and reorganization of the actin cytoskeleton (PubMed: 19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed: 2532504, PubMed: 8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity).

38,714

301

Annexin A1;Annexin I;Annexin-1;ANXA 1;ANXA1;Calpactin II;Calpactin-2;Chromobindin-9;Lipocortin I;p35;Phospholipase A2 inhibitory protein

ANXA1

Signal Transduction

ANXA1