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Home > Product > ELISA Kit > Human Integrin Alpha-V, ITGAV ELISA Kit

Human Integrin Alpha-V, ITGAV ELISA Kit

Human Integrin Alpha-V, ITGAV ELISA Kit

Product Summary

Size: 48T,96T

Sensitivity: 2.62ng/L

Detection range: 5-2000ng/L

Sample type: Serum, plasma, cell culture supernates

Reactive with: Human

Product Summary

Size: 48T,96T

Sensitivity: 2.62ng/L

Detection range: 5-2000ng/L

Sample type: Serum, plasma, cell culture supernates

Reactive with: Human

Product overview

Full product name

Integrin Alpha-V

Code

E3734Hu

Assay type

Sandwich

Size

48T,96T

Sensitivity

2.62ng/L

Detection range

5-2000ng/L

Sample type

Serum, plasma, cell culture supernates

Species

Human

Storage

2-8ºC

Assay time

1h 30m

Background

The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, Matrix Metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed: 23125415). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed: 20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed: 18441324). ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (PubMed: 28302677). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed: 19578119). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed: 28873464). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (PubMed: 29030430). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed: 18635536, PubMed: 25398877). ITGAV:ITGB3 and ITGAV:ITGB6 act as a receptor for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (PubMed: 12807887, PubMed: 17158881). Integrin alpha-V/beta-6 or alpha-V/beta-8 (ITGAV:ITGB6 or ITGAV:ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated Peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed: 15184403, PubMed: 22278742, PubMed: 28117447). ITGAV:ITGB3 act as a receptor for CD40LG (PubMed: 31331973). (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for Adenovirus type C. (Microbial infection) Integrin ITGAV:ITGB5 and ITGAV:ITGB3 act as receptors for Coxsackievirus A9 and B1. (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Herpes virus 8/HHV-8. (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for herpes simplex 1/HHV-1. (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Human parechovirus 1. (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for West nile virus. (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

UniProt accession

MASS(Da)

116,038

GeneID

3685

Synonyms

CD antigen CD51;Integrin alpha-V;Integrin alpha-V heavy chain;Integrin alpha-V light chain;ITGAV;Vitronectin receptor;Vitronectin receptor subunit alpha

Gene names

ITGAV

Research area

Cardiovascular

Target protein

ITGAV

Components

Components Quantity
Pre-coated ELISA Plate 12 * 8 well strips x1
Standard solution 0.5ml x1
Standard diluent 3ml x1
Streptavidin-HRP 6ml x1
Stop solution 6ml x1
Substrate solution A 6ml x1
Substrate solution B 6ml x1
Wash buffer concentrate (25x) 20ml x1
Biotinylated antibody 1ml x1

Protocol data

These standard curves of E3734Hu are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

Concentration O.D. Average Corrected
1200ng/L 2.095 2.129 2.085
2.162
600ng/L 1.435 1.425 1.381
1.416
300ng/L 0.606 0.623 0.579
0.639
150ng/L 0.441 0.446 0.402
0.45
75ng/L 0.155 0.168 0.125
0.182
0ng/L 0.036 0.044 0
0.051

Precision

We measured random samples of E3734Hu within the same batch/lot to ensure the consistency of the kits' performances.

Intra/Inter-Assay Sample n Mean Standard Deviation CV%
Intra-Assay 1 18 800 30.73 3.8
Intra-Assay 2 18 266.8 15.71 5.9
Intra-Assay 3 18 464 18.64 4

Protocols

Customer reviews and Q&As

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Associated products

  • Size

    Code

    Price

  • 48T

    E3734Hu

    $320.00

  • 96T

    E3734Hu

    $458.00

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Lead time: Within two weeks

We are continuously updating our ELISA Kit catalog with advanced verified products. If you can not download the datasheet please send your request of our latest datasheet.

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