Phospholipase A2

E4468Hu

Sandwich

48T,96T

0.29ng/ml

0.5-180ng/ml

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Secretory calcium-dependent phospholipase A2 that primarily targets dietary phospholipids in the intestinal tract (PubMed: 1420353, PubMed: 10681567, PubMed: 17603006). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (PubMed: 1420353, PubMed: 10681567, PubMed: 17603006). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation in the intestinal tract. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (By similarity). May act in an autocrine and paracrine manner (PubMed: 7721806, PubMed: 25335547). Upon binding to the PLA2R1 receptor can regulate podocyte survival and glomerular homeostasis (PubMed: 25335547). Has anti-helminth activity in a process regulated by gut microbiota. Upon helminth infection of intestinal epithelia, directly affects phosphatidylethanolamine contents in the membrane of helminth larvae, likely controlling an array of phospholipid-mediated cellular processes such as membrane fusion and cell division while providing for better immune recognition, ultimately reducing larvae integrity and infectivity (By similarity).

16,360

5319

Group IB phospholipase A2;Phosphatidylcholine 2-acylhydrolase 1B;Phospholipase A2;PLA2G1B

PLA2G1B

Metabolism

PLA2G1B