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Home > Product > ELISA Kit > Human Interleukin-17 Receptor C, IL17RC ELISA Kit

Human Interleukin-17 Receptor C, IL17RC ELISA Kit

Human Interleukin-17 Receptor C, IL17RC ELISA Kit

Product Summary

Size: 48T,96T

Sensitivity: 0.027ng/ml

Detection range: 0.05-20ng/ml

Sample type: Serum, plasma, cell culture supernates

Reactive with: Human

Product Summary

Size: 48T,96T

Sensitivity: 0.027ng/ml

Detection range: 0.05-20ng/ml

Sample type: Serum, plasma, cell culture supernates

Reactive with: Human

Product overview

Full product name

Interleukin-17 Receptor C

Code

E5512Hu

Assay type

Sandwich

Size

48T,96T

Sensitivity

0.027ng/ml

Detection range

0.05-20ng/ml

Sample type

Serum, plasma, cell culture supernates

Species

Human

Storage

2-8ºC

Assay time

1h 30m

Background

Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity (By similarity). Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA (PubMed: 16785495). Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA (PubMed: 18684971). Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA (PubMed: 17911633). Upon binding of IL17F homodimer triggers downstream activation of TRAF6 and NF-kappa-B signaling pathway (PubMed: 16785495, PubMed: 32187518). Induces transcriptional activation of IL33, a potent cytokine that stimulates group 2 innate lymphoid cells and adaptive T-helper 2 cells involved in pulmonary allergic response to fungi (By similarity). Promotes sympathetic innervation of peripheral organs by coordinating the communication between gamma-delta T cells and parenchymal cells. Stimulates sympathetic innervation of thermogenic adipose tissue by driving TGFB1 expression (By similarity). Binding of IL17A-IL17F to IL17RA-IL17RC heterodimeric receptor complex triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial Peptides and Matrix Metalloproteinases, with potential strong immune inflammation (PubMed: 18684971, PubMed: 17911633). Primarily induces neutrophil activation and recruitment at infection and inflammatory sites (By similarity). Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity). [Isoform 5]: Receptor for both IL17A and IL17F. [Isoform 6]: Does not bind IL17A or IL17F. [Isoform 7]: Does not bind IL17A or IL17F. [Isoform 8]: Receptor for both IL17A and IL17F.

UniProt accession

MASS(Da)

86,240

GeneID

84818

Synonyms

IL 17RC;IL-17 receptor C;IL17RC;IL-17RC;IL17Rhom;IL-17RL;Interleukin-17 receptor C;Interleukin-17 receptor homolog;Interleukin-17 receptor-like protein;ZcytoR14

Gene names

IL17RC

Research area

Immunology

Target protein

IL17RC

Components

Components Quantity
Pre-coated ELISA Plate 12 * 8 well strips x1
Standard solution 0.5ml x1
Standard diluent 3ml x1
Streptavidin-HRP 6ml x1
Stop solution 6ml x1
Substrate solution A 6ml x1
Substrate solution B 6ml x1
Wash buffer concentrate (25x) 20ml x1
Biotinylated antibody 1ml x1

Protocol data

These standard curves of E5512Hu are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

Concentration O.D. Average Corrected
12ng/ml 2.409 2.402 2.362
2.396
6ng/ml 1.516 1.471 1.431
1.425
3ng/ml 0.895 0.806 0.766
0.717
1.5ng/ml 0.523 0.519 0.479
0.516
0.75ng/ml 0.273 0.239 0.199
0.204
0ng/ml 0.031 0.04 0
0.049

Precision

We measured random samples of E5512Hu within the same batch/lot to ensure the consistency of the kits' performances.

Intra/Inter-Assay Sample n Mean Standard Deviation CV%
Intra-Assay 1 18 6 0.21 3.5
Intra-Assay 2 18 1.6 0.09 5.8
Intra-Assay 3 18 4.7 0.27 5.8

Protocols

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  • Size

    Code

    Price

  • 48T

    E5512Hu

    $320.00

  • 96T

    E5512Hu

    $458.00

Add to Cart

Lead time: Within two weeks

We are continuously updating our ELISA Kit catalog with advanced verified products. If you can not download the datasheet please send your request of our latest datasheet.

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