Slam Family Member 7

E6179Hu

Sandwich

48T,96T

14.56ng/L

30-9000ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed: 11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed: 16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed: 11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed: 23695528). Isoform 3 does not mediate any NK cell activation.

37,421

57823

CD antigen CD319;CD2 subset 1;CD2-like receptor-activating cytotoxic cells;CRACC;Membrane protein FOAP-12;Novel Ly9;Protein 19A;SLAM family member 7;SLAMF 7;SLAMF7

SLAMF7

Immunology

SLAMF7