Phospholipidase A2

E0267Mo

Sandwich

48T,96T

0.223ng/mL

0.5-150ng/mL

Serum, plasma, cell culture supernates

Mouse

2-8ºC

1h 30m

Secretory calcium-dependent phospholipase A2 that primarily targets dietary phospholipids in the intestinal tract (By similarity). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (By similarity). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation in the intestinal tract. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (By similarity). May act in an autocrine and paracrine manner (PubMed: 10066760). Upon binding to the PLA2R1 receptor can regulate podocyte survival and glomerular homeostasis (By similarity). Has anti-helminth activity in a process regulated by gut microbiota (PubMed: 29024642). Upon helminth infection of intestinal epithelia, directly affects phosphatidylethanolamine contents in the membrane of helminth larvae, likely controlling an array of phospholipid-mediated cellular processes such as membrane fusion and cell division while providing for better immune recognition, ultimately reducing larvae integrity and infectivity (PubMed: 29024642).

16,290

18778

Group IB phospholipase A2;Phosphatidylcholine 2-acylhydrolase 1B;Phospholipase A2;PLA2G1B;PLA2-Ib

PLA2G1B

Others

PLA2G1B