Nuclear Factor Erythroid 2-Related Factor 2

E1367Mo

Sandwich

48T,96T

0.108ng/ml

0.2-60ng/ml

Serum, plasma, cell culture supernates

Mouse

2-8ºC

1h 30m

Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzymes, and promotes their expression, thereby neutralizing reactive electrophiles (PubMed: 9240432, PubMed: 9887101, PubMed: 12032331, PubMed: 14517554, PubMed: 31398338). In normal conditions, ubiquitinated and degraded in the cytoplasm by the BCR(KEAP1) complex (PubMed: 15282312, PubMed: 15367669, PubMed: 15581590). In response to oxidative stress, electrophile metabolites inhibit activity of the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2, heterodimerization with one of the small Maf proteins and binding to ARE elements of cytoprotective target genes (PubMed: 12032331). The NFE2L2/NRF2 pathway is also activated in response to selective autophagy: autophagy promotes interaction between KEAP1 and SQSTM1/p62 and subsequent inactivation of the BCR(KEAP1) complex, leading to NFE2L2/NRF2 nuclear accumulation and expression of cytoprotective genes (PubMed: 20421418, PubMed: 20173742). May also be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region (By similarity).

66,901

18024

NFE2L2;NFE2-related factor 2;NF-E2-related factor 2;Nuclear factor erythroid 2-related factor 2;Nuclear factor, erythroid derived 2, like 2

NFE2L2

Cardiovascular

NFE2L2