High Mobility Group Protein B2

E2133Mo

Sandwich

48T,96T

0.056ng/mL

0.1-40ng/mL

Serum, plasma, cell culture supernates

Mouse

2-8ºC

1h 30m

Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (By similarity). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (PubMed: 9184213). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (PubMed: 19890330). In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE (By similarity). Has antimicrobial activity in gastrointestinal epithelial tissues (By similarity). Involved in inflammatory response to antigenic stimulus coupled with proinflammatory activity (PubMed: 25306442). May play a role in germ cell differentiation (PubMed: 11262228). Involved in modulation of neurogenesis probably by regulation of neural stem proliferation (PubMed: 24391977). Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (PubMed: 19805379).

24,162

97165

High mobility group protein 2;High mobility group protein B2;HMG-2;HMGB 2;HMGB2

HMGB2

Epigenetics and Nuclear Signaling

HMGB2