Phosphatidylcholine-Sterol Acyltransferase

E2340Mo

Sandwich

48T,96T

0.11ng/mL

0.2-60ng/mL

Serum, plasma, cell culture supernates

Mouse

2-8ºC

1h 30m

Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs) (PubMed: 19065001). The cholesterol ester is then transported back to the liver. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels (PubMed: 19065001). Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins (PubMed: 19065001). Required for remodeling high-density lipoprotein particles into their spherical forms (PubMed: 19065001). Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines (PubMed: 8820107). Catalyzes the hydrolysis of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor or PAF) to 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (PubMed: 10393212). Also catalyzes the transfer of the acetate group from PAF to 1-hexadecanoyl-sn-glycero-3-phosphocholine forming lyso-PAF (By similarity). Catalyzes the esterification of (24S)-hydroxycholesterol (24(S)OH-C), also known as cerebrosterol to produce 24(S)OH-C monoesters (By similarity).

49,747

16816

1-alkyl-2-acetylglycerophosphocholine esterase;LCAT;Lecithin-cholesterol acyltransferase;PAF acetylhydrolase;Phosphatidylcholine-sterol acyltransferase;Phospholipid-cholesterol acyltransferase;Platelet-activating factor acetylhydrolase

LCAT

Cardiovascular

LCAT