Neuregulin 1

E0537Ra

Sandwich

48T,96T

0.26ng/mL

0.5-100ng/mL

Serum, plasma, cell culture supernates

Rat

2-8ºC

1h 30m

Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Binds to ERBB4 and ERBB3. Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling (By similarity). Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1, and ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (PubMed: 17250808).

73,288

112400

Acetylcholine receptor-inducing activity;ARIA;Glial growth factor;Heregulin;HRG;Neu differentiation factor;Neuregulin-1;NRG 1;NRG1;Pro-neuregulin-1, membrane-bound isoform;Pro-NRG1;Sensory and motor neuron-derived factor

NRG1

Others

NRG1