Myelin Associated Glycoprotein

E1102Ra

Sandwich

48T,96T

0.051ng/ml

0.1-40ng/ml

Serum, plasma, cell culture supernates

Rat

2-8ºC

1h 30m

Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (PubMed: 8995428, PubMed: 9298990). Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane (By similarity). Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides (PubMed: 17640868). In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides (PubMed: 17640868). In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides (PubMed: 19367338). Inhibits axon longitudinal growth (PubMed: 9298990). Inhibits axon outgrowth by binding to RTN4R (By similarity). Preferentially binds to alpha-2,3-linked sialic acid (PubMed: 8995428). Binds ganglioside Gt1b (PubMed: 8995428).

69,353

29409

1B236;Brain neuron cytoplasmic protein 3;MAG;Myelin-associated glycoprotein;Sialic acid-binding Ig-like lectin 4a;Siglec-4a

MAG

Neuroscience

MAG