Hypoxia-Inducible Factor 1 alpha

E0422Hu

Sandwich

96T,48T

0.01ng/ml

0.05-15ng/ml

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia. (Microbial infection) Upon infection by human coronavirus SARS-CoV-2, is required for induction of glycolysis in monocytes and the consequent proinflammatory state (PubMed: 32697943). In monocytes, induces expression of ACE2 and cytokines such as IL1B, TNF, IL6, and interferons (PubMed: 32697943). Promotes human coronavirus SARS-CoV-2 replication and monocyte inflammatory response (PubMed: 32697943).

92,670

3091

ARNT-interacting protein;Basic-helix-loop-helix-PAS protein MOP1;bHLHe78;Class E basic helix-loop-helix protein 78;HIF 1A;HIF1A;HIF1-alpha;HIF-1-alpha;Hypoxia-inducible factor 1-alpha;Member of PAS protein 1;PAS domain-containing protein 8

HIF1A

Epigenetics and Nuclear Signaling

HIF1A