Aryl Hydrocarbon Receptor

E0664Hu

Sandwich

96T,48T

5.25ng/L

10-2000ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Ligand-activated transcription factor that enables cells to adapt to changing conditions by sensing compounds from the environment, diet, microbiome and cellular metabolism, and which plays important roles in development, immunity and cancer (PubMed: 30373764, PubMed: 23275542, PubMed: 7961644, PubMed: 32818467). Upon ligand binding, translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE) (PubMed: 30373764, PubMed: 23275542, PubMed: 7961644). Regulates a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (PubMed: 12213388). Xenobiotics can act as ligands: upon xenobiotic-binding, activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) (PubMed: 7961644). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons (PubMed: 7961644). Next to xenobiotics, natural ligands derived from plants, microbiota, and endogenous metabolism are potent AHR agonists (PubMed: 18076143). Tryptophan (Trp) derivatives constitute an important class of endogenous AHR ligands (PubMed: 32866000, PubMed: 32818467). Acts as a negative regulator of anti-tumor immunity: indoles and kynurenic acid generated by Trp catabolism act as ligand and activate AHR, thereby promoting AHR-driven cancer cell motility and suppressing adaptive immunity (PubMed: 32818467). Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1 (PubMed: 28602820). Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1 (PubMed: 28602820). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed: 28602820).

96,147

196

Ah receptor;AHR;Aryl hydrocarbon receptor;bHLHe76;Class E basic helix-loop-helix protein 76

AHR

Epigenetics and Nuclear Signaling

AHR