Progranulin

E1755Hu

Sandwich

48T,96T

5.12ng/ml

10-700ng/ml

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation (PubMed: 28541286, PubMed: 28073925, PubMed: 18378771, PubMed: 28453791, PubMed: 12526812). Regulates protein trafficking to lysosomes and, also the activity of lysosomal enzymes (PubMed: 28453791, PubMed: 28541286). Facilitates also the acidification of lysosomes, causing degradation of mature CTSD by CTSB (PubMed: 28073925). In addition, functions as wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures (By similarity). Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases (PubMed: 12526812). Moreover, modulates inflammation in neurons by preserving neurons survival, axonal outgrowth and neuronal integrity (PubMed: 18378771). [Granulin-4]: Promotes proliferation of the epithelial cell line A431 in culture. [Granulin-3]: Inhibits epithelial cell proliferation and induces epithelial cells to secrete IL-8. [Granulin-7]: Stabilizes CTSD through interaction with CTSD leading to maintain its aspartic-type peptidase activity.

63,544

2896

Acrogranin;Epithelin precursor;Epithelin-1;Epithelin-2;Glycoprotein 88;Glycoprotein of 88 Kda;GP88;Granulin A;Granulin B;Granulin C;Granulin D;Granulin E;Granulin F;Granulin G;Granulin precursor;Granulin-1;Granulin-2;Granulin-3;Granulin-4;Granulin-5;Granulin-6;Granulin-7;GRN;Paragranulin;PC cell-derived growth factor;PCDGF;PEPI;PGRN;Proepithelin;Progranulin

GRN

Neuroscience

GRN