Proinsulin

E0390Mo

Sandwich

48T,96T

0.56ng/L

1-400ng/L

Serum, plasma, cell culture supernates

Mouse

2-8ºC

1h 30m

Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation (PubMed:28073925, PubMed:8496151, PubMed:28541286, PubMed:28453791, PubMed:20026663, PubMed:23041626, PubMed:27789271, PubMed:12524533). Regulates protein trafficking to lysosomes and, also the activity of lysosomal enzymes (PubMed:28453791, PubMed:28541286, PubMed:27789271). Facilitates also the acidification of lysosomes, causing degradation of mature CTSD by CTSB (PubMed:28073925). In addition, functions as wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures (PubMed:12524533). Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases (PubMed:8496151). Moreover, modulates inflammation in neurons by preserving neurons survival, axonal outgrowth and neuronal integrity (PubMed:23041626, PubMed:20026663). Inhibits epithelial cell proliferation and induces epithelial cells to secrete IL-8. Stabilizes CTSD through interaction with CTSD leading to maintain its aspartic-type peptidase activity.

63,458

14824

Acrogranin;epit;Epithelin/granulin precursor;Glycoprotein 88;Glycoprotein of 88 Kda;GP88;Granulin-1;Granulin-2;Granulin-3;Granulin-4;Granulin-5;Granulin-6;Granulin-7];Paragranulin;PC cell-derived growth factor;PCDGF;PEPI;Pgrn;PI;pr;Proepithelin;Progranulin;

Grn

Signal Transduction; Cancer; Immunology

PI