Product name
Recombinant Mouse MIG/CXCL9 protein
Code
CD00299
Biological activity
Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human lymphocytes is in a concentration range of 0.1-1.0 ng/ml.
Endotoxin
Less than 1 EU/μg of rMuMIG/CXCL9 as determined by LAL method.
Synonyms
MIG/CXCL9, BB139920, CMK, Mi, Mig, MuMIG, Scyb, Scyb9, crg-1, crg-10,Mouse
Sequence
TLVIRNARCS CISTSRGTIH YKSLKDLKQF APSPNCNKTE IIATLKNGDQ TCLDPDSANV KKLMKEWEKK INQKKKQKRG KKHQKNMKNR KPKTPQSRRR SRKTT
Uniprot Accession
Molecular Weight
Approximately 12.2 kDa, a single non-glycosylated polypeptide chain containing 105 amino acids.
Formulation
Lyophilized from a 0.2 μm filtered concentrated solution in 2 × PBS, pH 7.4.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
Background
CXCL9 belongs to the CXC chemokine family and also known as Monokine induced by gamma interferon (MIG). It is a T-cell chemoattractant induced by IFN-γ. CXCL9 is closely related to two other CXC chemokines called CXCL10 and CXCL11, additionally they all elicit their chemotactic functions by interacting with the chemokine receptor CXCR3. It is a cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response and chemotactic for activated T-cells. Recombinant Mouse CXCL9 contains 105 amino acids which is a single non-glycosylated polypeptide chain. Furthermore, The Mouse CXCL9 shares 75 % and 88 % a.a. sequence identity with human and rat CXCL9.
Storage
-20ºC
Research area
Immunology
