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Home > Product > Antibody > CD40 Monoclonal Antibody

CD40 Monoclonal Antibody

CD40 Monoclonal Antibody

Product Summary

Size: 50ul,100ul

Clonality: Monoclonal

Host: Mouse

Reactivity:Human

Applications: IF, ICC, ELISA

Product Summary

Size: 50ul,100ul

Clonality: Monoclonal

Host: Mouse

Reactivity: Human

Applications: IF, ICC, ELISA

Product overview

Full product name

Tumor necrosis factor receptor superfamily member 5

Code

BT-MCA0305

Host

Mouse

Isotype

IgG

Size

50ul,100ul

Clonality

Monoclonal

Immunogen

Purified recombinant fragment of CD40 expressed in E. Coli.

Purification

Affinity purification

Concentration

1 mg/ml

Formulation

Purified recombinant fragment of CD40 expressed in E. Coli.

Storage

-20°C for one year

Background

This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIG

Uniprot accession

Molecular weight

N/A

Gene ID

Human: 958

Synonyms

CD40; TNFRSF5; Tumor necrosis factor receptor superfamily member 5; B-cell surface antigen CD40; Bp50; CD40L receptor; CDw40; CD antigen CD40

Research area

Immunology; Stem cells; Cardiovascular

Target protein

CD40

Recommended dilution

Application Dilution
ELISA 1:10000
IF 1:200 - 1:1000

Images

Confocal immunofluorescence analysis of human peripheral blood lymphocyles (left) and mouse L1210 cells (right) using CD40 Monoclonal antibody (green). Blue: DRAQ5 fluorescent DNA dye.

Protocols

Customer reviews and Q&As

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Product size

Price

  • 50ul

    $180.00

  • 100ul

    $300.00

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Lead time: Within one week

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