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Home > Product > Antibody > TORC1 Monoclonal Antibody

TORC1 Monoclonal Antibody

TORC1 Monoclonal Antibody

Product Summary

Size: 50ul,100ul

Clonality: Monoclonal

Host: Mouse

Reactivity:Human, Mouse, Rat, Pig

Applications: WB, FCM, IF, ICC

Product Summary

Size: 50ul,100ul

Clonality: Monoclonal

Host: Mouse

Reactivity: Human,Mouse,Rat,Pig

Applications: WB, FCM, IF, ICC

Product overview

Full product name

CREB-regulated transcription coactivator 1

Code

BT-MCA1215

Host

Mouse

Isotype

IgG

Size

50ul,100ul

Clonality

Monoclonal

Immunogen

Purified recombinant human TORC1 (N-terminus) protein fragments expressed in E.coli.

Purification

Affinity purification

Concentration

1 mg/ml

Formulation

Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.

Storage

-20°C for one year

Background

A chromosomal aberration involving CRTC1 is found in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. Translocation t(11|19)(q21|p13) with MAML2. The fusion protein consists of the N-terminus of CRTC1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of CRTC1 has been detected in a small number of mucoepidermoid carcinomas.,function:Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4.

Uniprot accession

Molecular weight

N/A

Gene ID

Human: 23373; Mouse: 382056; Rat: 684527

Synonyms

CRTC1; KIAA0616; MECT1; TORC1; WAMTP1; CREB-regulated transcription coactivator 1; Mucoepidermoid carcinoma translocated protein 1; Transducer of regulated cAMP response element-binding protein 1; TORC-1; Transducer of CREB protein 1

Research area

Signal transduction; Metabolism; Epigenetics and nuclear signaling

Target protein

CRTC1

Recommended dilution

Application Dilution
FC 1:100 - 1:200
IF 1:100 - 1:500
WB 1:1000 - 1:2000

Images

Western Blot analysis using TORC1 Monoclonal antibody against HeLa, Jurkat cell lysate.
Flow cytometric analysis of K562 cells stained with TORC1 Monoclonal antibody (red), followed by FITC-conjugated goat anti-mouse IgG. Blue line histogram represents the isotype control, normal mouse IgG.

Protocols

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Product size

Price

  • 50ul

    $180.00

  • 100ul

    $300.00

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Lead time: Within one week

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