Tel:86 021 3100 7137

Publish and get free product : share with us your publications using BT LAB product and get free products.
Home > Product > Antibody > RANKL Polyclonal Antibody

RANKL Polyclonal Antibody

RANKL Polyclonal Antibody

Product Summary

Size: 20ul,50ul,100ul

Clonality: Polyclonal

Host: Rabbit

Reactivity:Human, Mouse, Rat

Applications: WB, IF, ICC, ELISA

Product Summary

Size: 20ul,50ul,100ul

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IF, ICC, ELISA

Product overview

Full product name

Tumor necrosis factor ligand superfamily member 11

Code

BT-AP07786

Host

Rabbit

Isotype

IgG

Size

20ul,50ul,100ul

Clonality

Polyclonal

Immunogen

The antiserum was produced against synthesized peptide derived from human TNFSF11. AA range:41-90

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage

-20°C for 1 year

Background

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B ly

Uniprot accession

Molecular weight

35478

Gene ID

Human: 8600; Mouse: 21943; Rat: 117516

Synonyms

Tumor necrosis factor ligand superfamily member 11; TNFSF11; OPGL; RANKL; TRANCE; Tumor necrosis factor ligand superfamily member 11; Osteoclast differentiation factor; ODF; Osteoprotegerin ligand; OPGL; Receptor activator of nuclear factor kappa-B ligand; RANKL; TNF-related activation-induc

Research area

Cardiovascular; Immunology

Target protein

TNFSF11

Recommended dilution

Application Dilution
WB 1: 500 - 1: 2000
IF 1: 200 - 1: 1000
ICC 1: 200 - 1: 1000
ELISA 1: 40000

Images

Immunofluorescence analysis of HepG2 cells, using TNFSF11 Antibody. The picture on the right is blocked with the synthesized peptide.
Western Blot analysis of various cells using RANKL Polyclonal Antibody
Western blot analysis of lysates from HUVEC cells, using TNFSF11 Antibody. The lane on the right is blocked with the synthesized peptide.

Protocols

Customer reviews and Q&As

No reviews
No reviews

Product size

Price

  • 20ul

    $108.00

  • 50ul

    $180.00

  • 100ul

    $275.00

Add to Cart

Lead time: Within one week

We are continuously updating our Antibody catalog with advanced verified products. If you can not download the datasheet please send your request of our latest datasheet.

Newsletter

Sign up

Newsletter

Sign up