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Home > Product > Antibody > Shh Polyclonal Antibody

Shh Polyclonal Antibody

Shh Polyclonal Antibody

Product Summary

Size: 20ul,50ul,100ul

Clonality: Polyclonal

Host: Rabbit

Reactivity:Human, Mouse, Rat

Applications: IHC-p, IF, WB

Product Summary

Size: 20ul,50ul,100ul

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: IHC-p, IF, WB

Product overview

Full product name

Shh

Code

BT-AP07978

Host

Rabbit

Isotype

IgG

Size

20ul,50ul,100ul

Clonality

Polyclonal

Immunogen

Synthesized peptide derived from human Shh

Purification

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration

1 mg/ml

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage

-20°C for 1 year

Background

This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube| the anterior-posterior limb axis| and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila| this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly| the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product| restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE)| a d

Uniprot accession

Gene ID

Human: 6469

Synonyms

Shh; Sonic hedgehog protein; SHH; HHG-1; Sonic hedgehog protein N-product; Sonic hedgehog protein C-product;

Research area

Developmental biology; Cancer; Epigenetics and nuclear signaling; Metabolism; Stem cells

Target protein

SHH

Recommended dilution

Application Dilution
WB 1: 500 - 1: 2000
IHC-p 1: 50 - 1: 200

Images

Western blot analysis of lysates from Jarkat cells, primary antibody was diluted at 1:1000, 4°C overnight

Protocols

Customer reviews and Q&As

No reviews
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Product size

Price

  • 20ul

    $108.00

  • 50ul

    $180.00

  • 100ul

    $275.00

Add to Cart

Lead time: Within one week

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