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Home > Product > Antibody > Collagen XVIII alpha 1(Cleaved-His1572) Rabbit Polyclonal Antibody

Collagen XVIII alpha 1(Cleaved-His1572) Rabbit Polyclonal Antibody

Collagen XVIII alpha 1(Cleaved-His1572) Rabbit Polyclonal Antibody

Product Summary

Size: 100ul,50ul,20ul

Clonality: Polyclonal

Host: Rabbit

Reactivity:Human, Mouse

Applications: WB, ELISA

Product Summary

Size: 100ul,50ul,20ul

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB, ELISA

Product overview

Full product name

Collagen XVIII alpha 1

Code

BT-AP08259

Host

Rabbit

Isotype

IgG

Size

100ul,50ul,20ul

Clonality

Polyclonal

Immunogen

Synthesized peptide derived from human Collagen XVIII α1 (Cleaved-His1572)

Purification

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration

1 mg/ml

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage

-20°C for 1 year

Background

This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins| extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin| a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities| so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants.

Uniprot accession

Molecular weight

192940

Gene ID

Human: 80781; Mouse: 12822

Synonyms

Collagen XVIII α1 ;Cleaved-His1572; Collagen alpha-1;XVIII chain [Cleaved into: Endostatin;

Research area

Cancer; Cardiovascular; Signal transduction

Target protein

COL18A1

Recommended dilution

Application Dilution
WB 1: 1000 - 1: 2000
ELISA 1: 5000 - 1: 20000

Protocols

Customer reviews and Q&As

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Product size

Price

  • 100ul

    $275.00

  • 50ul

    $180.00

  • 20ul

    $108.00

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Lead time: Within one week

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