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Home > Product > Antibody > GNAS2 Rabbit Polyclonal Antibody

GNAS2 Rabbit Polyclonal Antibody

GNAS2 Rabbit Polyclonal Antibody

Product Summary

Size: 100ul,50ul,20ul

Clonality: Polyclonal

Host: Rabbit

Reactivity:Human, Mouse, Rat

Applications: WB

Product Summary

Size: 100ul,50ul,20ul

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

Product overview

Full product name

GNAS2

Code

BT-AP10202

Host

Rabbit

Isotype

IgG

Size

100ul,50ul,20ul

Clonality

Polyclonal

Immunogen

Synthesized peptide derived from human GNAS2

Purification

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration

1 mg/ml

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage

-20°C for 1 year

Background

This locus has a highly complex imprinted expression pattern. It gives rise to maternally| paternally| and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons| and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus| and the antisense transcript| are paternally expressed noncoding RNAs| and may regulate imprinting in this region. In addition| one of the transcripts contains a second overlapping ORF| which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed| which results in different forms of the stimulatory G-protein alpha subunit| a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a| pseudohypoparathyroidism type 1b| Albright hereditary osteodystrophy| pseudopseudohypoparathyroidism| McCune-Albright syndrome| progressive osseus heteroplasia| polyostotic fibrous dysplasia of bone| and some pituitary tumors.

Uniprot accession

Molecular weight

43340

Gene ID

Human: 2778; Mouse: 14683; Rat: 24896

Synonyms

GNAS2

Research area

Cancer; Metabolism; Signal transduction

Target protein

GNAS

Recommended dilution

Application Dilution
WB 1: 500 - 1: 2000

Images

Western blot analysis of lysates from Jarkat cells, primary antibody was diluted at 1:1000, 4°C overnight

Protocols

Customer reviews and Q&As

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Product size

Price

  • 100ul

    $275.00

  • 50ul

    $180.00

  • 20ul

    $108.00

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Lead time: Within one week

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